Genetics of ergoline alkaloid formation in Penicillium roquefortii.
نویسندگان
چکیده
Auxotrophic, spore color, and alkaloid biosynthetic mutants of Penicillium roquefortii were selected after N-methyl-N'-nitro-N-nitrosoguanidine treatment. Diploids were obtained via protoplast fusion techniques, and the segregants from a diploid were genetically analyzed. The data demonstrated the potential of parasexual recombination in this organism. Evidence was obtained which suggests that the his and sts (sensitivity to Sulfatase) genes may be linked. The genetic information obtained in this study can serve as a starting point for further mapping of genes in P. roquefortii, and indications are that this organism may serve as a promising vehicle for the genetic study of the formation of ergoline alkaloids.
منابع مشابه
Biologically active metabolites of Penicillium fungi
Penicillia are some of the most widespread hyphomycetes among microscopic fungi. Their natural habitats are soils of northern latitudes. They are known as producers of various types of biologically active compounds such as ergot alkaloids, diketopiperazines, quinolines, quinazolines and polyketides [1]. Penicillium fungi synthesize clavine ergot alkaloids whose structural specificity is that th...
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عنوان ژورنال:
- Applied and environmental microbiology
دوره 50 3 شماره
صفحات -
تاریخ انتشار 1985